Arsenal will be without defender Kolo Toure (groin) and midfielder Denilson (back) while Goalkeeper Lukasz Fabianski is set to make a rare start as manager Arsene Wenger looks set to include some of his fringe players, such as Wales midfielder Aaron Ramsey.
However, striker Eduardo remains in recovery following a broken leg, while captain Cesc Fabregas (knee), Theo Walcott (shoulder), and Tomas Rosicky (hamstring) are also sidelined.
Plymouth manager Paul Sturrock could hand a debut to new signing David Gray after he arrived on loan from Manchester United and will vie with Mat Doumbe for the right-back berth.
Winger Craig Noone has shrugged off the virus while skipper Karl Duguid is set to be recalled but transfer-listed midfielder Simon Walton misses out through suspension.