The man, in his 20s, was attacked at about 1645 BST outside McDonald’s on Oxford Street, near Oxford Circus.
Paramedics treated him at the scene before taking him to St Thomas’ Hospital where he was pronounced dead.
A post-mortem examination is expected to take place soon. No arrests have been made and no description of any suspects has been released.
Cordons are in place in Oxford Street between Oxford Circus and Tottenham Court Road.
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